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We are offering a PhD fellowship in the health effects of dairy matrix one human bone homeostasis commencing 1 April 2021.


Our group and research
The common research theme of the Molecular Pharmacology Laboratory (MolPharm) is the relationship between structure and function of 7TM (seven transmembrane segment), G protein-coupled receptors.
Structure-function studies of 7TM G protein coupled receptors within in particular the immune system (cytokine and lipid receptors) and the endocrine system (incretin, neuropeptide, melanocortin, melatonin, lipid and orphan receptors). This includes the molecular basis for ligand recognition and receptor activation, action of allosteric and orthosteric agonists, antagonists, super- and inverse agonists. Identification of novel compounds by site-directed drug discovery methods and chemogenomics. Description of signalling phenomena such as constitutive activity, functional selectivity (biased activity) and receptor cross-talk.

Project description

The project based on human studies, will investigate the physiological effects of different dairy and non-dairy whole food matrices of postprandial gastro-intestinal hormone secretion and bone remodeling in healthy humans. 

The gut is involved in multiple homeostatic processes by releasing a series of gut hormones upon food intake, to promote anabolic functions, including on the skeleton. Bone remodeling is the permanently process of bone formation and bone resorption. The homeostasis displays a circadian rhythm, with high bone resorption during the nighttime (when fasting) and low during the day (when we eat). The mechanism regulating this variation seems to be caused by the ingestion of a meal. Since bone turnover (bone formation and bone resorption) is suppressed upon nutrient stimulation, a gut-bone axis has been proposed in which GIP, GLP-2 and GLP-1 have been suggested as mediators. We, and others, have conducted several studies, including human trials, indicating that these three hormones inhibit bone resorption and, in addition, GIP seems to increases bone formation.

The overall purpose of this project is to gain a better understanding of the health effects of dairy product by exploring the dairy matrix effect on bone metabolism in healthy humans.


Principal supervisor
Principal supervisor is Professor Mette Marie Rosenkilde, Department of Biomedical Sciences. Telephone: 0045 3060 4608, e-mail: rosenkilde@sund.ku.dk

Start:                1 April  2021

Duration:         3 years as a PhD student

 If relevant, employment as research assistant for a month prior to the PhD position.

Job description
Your key tasks as a PhD student at SUND are:

  • Carry through an independent research project under supervision
  • Complete PhD courses or other equivalent education corresponding to approx. 30 ECTS points
  • Participate in active research environments including a stay at another research team
  • Obtain experience with teaching or other types of dissemination related to your PhD project
  • Teach and disseminate your knowledge
  • Write a PhD thesis on the grounds of your project

Key criteria for the assessment of applicants

  • Applicants must have qualifications corresponding to a master’s degree related to the subject area of the project e.g. a Master in Food Science, Dairy Science and Technology, Medicine or another equivalent degree
  • A special interest and competencies in physiological effects of different dairy and non-dairy whole food matrices of postprandial gastro-intestinal hormone secretion and bone remodeling
  • High level of motivation, responsibility and team-oriented personality
  • Excellent communication skills in English (written and oral)
  • Competences with writing research-funding applications as the project is partly funded
  • An interest and knowledge to perform a research project in ´whole´ dairy matrix effects
  • Knowledge in gut hormones: GIP, GLP-1, GLP-2 and preferably the gut-bone axis

Place of employment

The place of employment is at Department of Biomedical Sciences, Faculty of Health and Medical Sciences, University of Copenhagen. We offer creative and stimulating working conditions in dynamic and international research environment.


Terms of employment
The employment as PhD fellow is full time and for 3 years. The position is covered by the Memorandum on Job Structure for Academic Staff.

Terms of appointment and payment accord to the agreement between the Ministry of Finance and The Danish Confederation of Professional Associations on Academics in the State. The starting salary is currently at a minimum annual DKK 331,125 (approx. €43,750) including annual supplement (+ pension at a minimum DKK 53,811). Negotiation for salary supplement is possible.

It is conditioned upon the applicant’s success­ful enrolment as a PhD student at the Graduate School at the Faculty of Health and Medical Sciences, University of Copenhagen. This requires submission and acceptance of an application for the specific project formulated by the applicant.

The PhD study must be completed in accordance with The Ministerial Order on the PhD programme (2013) and the Faculty’s rules on achieving the degree.

Questions
For specific information about the PhD fellowship, please contact the principal supervisor.

General information about PhD study at the Faculty of Health and Medical Sciences is available at the Graduate School’s website: https://healthsciences.ku.dk/phd/guidelines/

Application procedure
Your application must be submitted electronically by clicking ‘Apply now’ below. The application must include the following documents in PDF format: 

1. Motivated letter of application (max. one page)

2. CV incl. education, experience, language skills and other skills relevant for the position

3. Master of Science diploma and transcript of records. If not completed, a certified/signed copy of a recent transcript of records or a written statement from the institution or supervisor will do

4. Publication list (if possible)


Application deadline: 20 January 2021, 23.59pm CET

We reserve the right not to consider material received after the deadline, and not to consider applications that do not live up to the abovementioned requirements.

The further process
After the expiry of the deadline for applications, the authorized recruitment manager selects applicants for assessment on the advice of the hiring committee. All applicants are then immediately notified whether their application has been passed for assessment by an unbiased assessor.

The assessor makes a non-prioritized assessment of the academic qualifications and experience with respect to the above-mentioned area of research, techniques, skills and other requirements listed in the advertisement.

Once the assessment work has been completed each applicant has the opportunity to comment on the part of the assessment that relates to the applicant him/herself.


You can read about the recruitment process at https://employment.ku.dk/faculty/recruitment-process/

The applicant will be assessed according to the Ministerial Order no. 242 of 13 March 2012 on the Appointment of Academic Staff at Universities.

Interviews are expected to be held in week 6-7.

The Faculty of Health and Medical Sciences comprises approximately 7500 students, 1500 PhD students and 3200 employees. The Faculty advances the field of health sciences through its core activities: research, teaching, knowledge sharing and communication. With basic research fields ranging from molecular studies to studies of society, the Faculty contributes to a healthy future through its graduates, research findings and inventions benefitting patients and the community. The University of Copenhagen wishes to reflect the surrounding community and invites all regardless of personal background to apply for the position. 

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Part of the International Alliance of Research Universities (IARU), and among Europe’s top-ranking universities, the University of Copenhagen promotes research and teaching of the highest international standard. Rich in tradition and modern in outlook, the University gives students and staff the opportunity to cultivate their talent in an ambitious and informal environment. An effective organisation – with good working conditions and a collaborative work culture – creates the ideal framework for a successful academic career.


Contact

Mette RosenkildeE-mail: rosenkilde@sund.ku.dk

Info

Application deadline: 20-01-2021

Employment start: 01-04-2021

Working hours: Full time

Department/Location: Department of Biomedical Sciences

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