The NEOtrap is formed by a DNA-origami structure docked onto a nanopore to (i) form a nanoscale cavity, and (ii) induce an electro-osmotic trapping potential. This allows us to sense the behaviour of a single protein over time, similar to smFRET or optical/magnetic tweezers. The big advantage is however that the NEOtrap works label-free using native proteins, is not limited by photo-bleaching, and does not rely on mechanical unfolding. The NEOtrap is further unique, in that it covers an exceptional time bandwidth (microseconds to hours), which is ideal to detect the broad range dynamics observed in proteins. The NEOtrap has already proven to distinguish not only proteins of different molecular weight, but even nucleotide-dependent conformations of the same protein, which demonstrates excellent sensitivity thus opening the way for many exciting next steps including electrical detection of protein dynamics, enzymatic reactions, protein fingerprinting, electro-optical combinations etc. The position is shared between the labs of Cees Dekker at TU Delft, NL, www.ceesdekkerlab.nl and Sonja Schmid at WUR, NL, www.NanoDynamicsLab.nl .
- a PhD in (bio)physics, biochemistry, interdisciplinary nanosciences or related fields and a fundamental interest in single-molecule studies and protein dynamics;
- a strong background in one or several of the following research fields: experience in single-molecule experiments, protein biophysics, nanofluidics/nanopore detection, advanced data analysis and pattern recognition;
- an independent, well-organized and reliable work style, enthusiasm for the project, and a strong drive to do interdisciplinary experimental research;
- a social team player attitude and good communication skills in English;
- a profound interest in the broader field of single-molecule protein science to contribute to our open and interactive lab culture.
A stimulating position with a competitive salary from a minimum of € 3217,- to a maximum of € 4402,- (depending on your experience) for a full working week of 38 hours in accordance with the Collective Labor Agreement Dutch Universities (scale 10). We offer a temporary position for 2 years with a contract for one year at the WUR and one year at the TU Delft and potential extension.
In addition, we offer:
- 8% holiday allowance;
- a structural year-end bonus of 8.3%;
- excellent training opportunities and secondary employment conditions;
- flexible working hours and holidays can possibly be determined in consultation so that an optimal balance between work and private life is possible;
- excellent pension plan through ABP;
- 232 vacation hours, the option to purchase extra and good supplementary leave schemes;
- a flexible working time: the possibility to work a maximum of 2 hours per week extra and thereby to build up extra leave;
- a choice model to put together part of your employment conditions yourself, such as a bicycle plan;
- a lively workplace where you can easily make contacts and where many activities take place on the Wageningen Campus. A place where education, research and business are represented;
- use the sports facilities on campus.
Wageningen University & Research stimulates internal career opportunities and mobility with an internal recruitment policy. There are ample opportunities for own initiative in a learning environment.
We offer a versatile job in an international environment with varied activities in a pleasant and open working atmosphere.
For more information about this vacancy, please contact Dr Sonja Schmid, Assistant Professor of Biophysics, email: email@example.com and Prof. Cees Dekker at TU Delft: firstname.lastname@example.org.
For more information about the procedure, please contact Marjolijn Steffens, HR Advisor, email:
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The Laboratory of Biophysics (BIP) engages in research of the physical aspects of life processes and teaching of the fundamentals of physics and biophysics and their application in the life sciences. The research of BIP relies on both optical and magnetic resonance techniques.
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