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The Division of Cell and Gene Therapy of the Center for Translational Neuromedicine (CTN) is looking for a highly motivated Research Assistant for the development and preparation of an enrollment as a PhD Fellow.


The position is a temporary position for 3 months. On the condition of a satisfying performance and of enrollment as PhD-student, we offer an additional three years of employment as a PhD-fellow.

Our research team

The Center for Translational Neuromedicine is part of the Faculty of Health and Medical Sciences, University of Copenhagen, and is located in the Panum Institute. For more information, visit https://ctn.ku.dk/.

This position offers the opportunity to work in a collaborative multi-disciplinary team engaged in translational stem cell research. Our efforts are focused on understanding the role of glia in several neurological and neuropsychiatric disorders (Huntington’s disease, schizophrenia, ALS-FTD and the childhood leukodystrophies). In particular, we are interested in defining the differences in the dynamic regulation of genes and signaling pathways in glial cells, as a way to identify novel therapeutic targets and to develop cell-based therapy strategies for the treatment of some of these disorders.

The Center is highly international, and thus our common language, both scientifically and socially, is English. The Center is a relatively new research unit; it is highly ambitious, fast-paced and hard-working. Our group has a strong collaboration with our sister lab in the US, and with corporate partners. The Division is currently composed of the Principal Investigator, 3 assistant professors and 6 PhD students, 2 staff scientists, research assistants and an animal caretaker, as well as undergraduate students and the Center administration. It works closely with the other divisions of the Center, as well as its sister lab in the US, which includes over 35 faculty and staff; a number of researchers have worked in and travel between both sites. Collaborations, and collaborative travel opportunities, exist with other labs in the US, as well as in Sweden, the UK, and Japan.


The Project

Glial cells are key contributors to a multitude of neurological disorders and pose tantalizing targets for cell replacement therapy. We are seeking an independent and highly motivated candidate to model human glial cell replacement in vivo, in humanized glial chimeric animals. The project aims to understand the molecular drivers of cell competition between healthy and diseased human glial cells, and to use that information to model the cell-based treatment of human neurodegenerative and neuropsychiatric diseases.

Applicants must have strong experience in both stem cell and neurobiology. The successful candidate will have a Master’s degree and at least 2 years bench cell and/or molecular biology experience. Experience in some combination of stem cell culture and differentiation, cloning and genetic editing, and histological processing and image analysis is needed, as is a strong interest in neuroscience.

The successful candidate should prepare a PhD project to be presented and discussed with the principal investigator prior to start.

Job description

  • Carry through an independent research project under supervision
  • Complete PhD courses or other equivalent education corresponding to approx. 30 ECTS points
  • Obtain experience with teaching or other types of dissemination related to your PhD project
  • Write a PhD thesis on the grounds of your project
     
    Preferred skills
  • Molecular cloning
  • Genetic editing
  • Cell culture
  • Stem cell differentiation
  • Histological processing
     
    Significant prior experience with at least some combination of these techniques is required. Additionally, candidates are expected to be proactive and independent in the lab, and able to both setup and troubleshoot new protocols as new experiments are designed. The ability to find a balance between learning fast and working independently, while being able to freely ask questions when unsure about any aspects of the work, is critical for any successful student.
     
    Key criteria in the assessment of applicants
  • Candidates for the PhD position must hold a Master’s degree in neuroscience, cell or molecular biology
  • At least 2 years of laboratory experience in cell culture and/or bench cell and molecular biology
  • The successful candidate needs to have a strong skill-set at the start of employment
  • The successful candidate will be organized, highly self-motivated, and independently self-sufficient
  • Most importantly, the successful candidate will be highly motivated, passionate for science, and driven to be a part of translational efforts
  • The successful candidate will possess strong English language written and oral communication skills
     
    Employment conditions
    Salary, pension and terms of employment will be in accordance with the agreement between the Danish Ministry of Finance and AC (Danish Confederation of Professional Associations). Working hours are 37 hours per week.

The position is a full-time position and is open from March 2021 or after agreement with the principal investigator. This is a 3-year position.

The successful candidate will report to Steve Goldman (Principal Investigator).

Further information on the Center can be found at https://ctn.ku.dk/. Inquiries about the position can be made to Professor Steven Goldman, goldman@sund.ku.dk or Administrator Ann Christensen, ann.christensen@sund.ku.dk.

Application
Your application in English must be submitted by clicking ‘Apply now’.  

Application deadline is January 15, 2021

Only online applications submitted through the job portal will be accepted and must include:  

  • Curriculum vitae – including a description of past education and relevant course and bench work
  • Cover letter stating the interest in and qualifications for the project, including a description of past experience, technical expertise, and relevant accomplishment            
  • Copy of relevant diplomas
  • Names and contact information of 3 references, with associated letters of recommendation

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