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A postdoc position is available in the laboratory of Guy G. Poirier in the Department of Molecular Biology, Medical Biochemistry, and Pathology (Faculty of Medicine) of Laval University. The laboratory is located at CHU de Quebec Research Center (CHUL), Oncology Division (Quebec City, Canada).
Inhibition of the early DNA damage signalling enzyme poly(ADP-ribose) polymerase-1 (PARP-1) is among the most promising therapies in cancer. PARP inhibitors sensitize cancer cells to DNA damaging agents and efficiently kill BRCA1/2-deficient breast and ovarian cancer cells, suggesting that defective DNA double-strand break (DSB) repair is reponsible for the observed sensitivity, a relationship that has been referred to as synthetic lethality. We seek highly motivated postdoc candidates with strong experimental skills and solid background in DNA damage signalling and repair pathways to study the mechanisms underlying the synthetic lethality between DSB repair deficiency and PARP inhibition.
The successful candidate will join a research team dedicated to the study of PARPs functions in DNA DSB processing and synthetic lethality, composed of postdocs, graduate students and research associates working on the identification and isolation of HR regulators in the context of PARP activation and the maintenance of geneome integrity. The postdoc project will focus on characterizing the role of PAR-associated factors in DNA repair and to investigate whether this process is altered in cancer cells, which could have implications for cancer therapy. A number of techniques required to study DNA repair are already up and running in our laboratory in addition to a wide array of methods developped for the study of PARP-1 and PAR. We are particularly interested in mass spectrometry-based identification of PAR-associated proteins for which our laboratory has partnered with proteomics facilities.
1. Caron MC, Sharma AK, O’Sullivan J, Myler LR, Ferreira MT, et al. 2019. Nat Commun 10: 2954
2. Gagne JP, Langelier MF, Pascal JM, Poirier GG. 2018. J Proteome Res 17: 2542-51
3. Gagne JP, Pic E, Isabelle M, Krietsch J, Ethier C, et al. 2012. Nucleic Acids Res 40: 7788-805
4. O’Sullivan J, Tedim Ferreira M, Gagne JP, Sharma AK, Hendzel MJ, et al. 2019. Nat Commun 10: 1182
We offer a full-time, two year term position, with the possibility of renewal based on need, funding and performance. Applicants should have a strong scientific track record with at least one publication as first author in a peer-reviewed journal. A background in chromatin biology, DNA damage response or mass spectrometry is a plus.
Please send your application as a composite pdf file in English to Guy.Poirier@crchudequebec.ulaval.ca. Please include a letter of motivation with your research interests (also highlighting your suitability for the position), a CV with publications and names and addresses of three referees. Position is available immediately and will remain open until a suitable candidate is found.