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We are currently seeking a highly-motivated postdoctoral scientist to work with Prof. Eoin Scanlan and Prof. Thorfinnur Gunnlaugsson on a collaborative, Organic Chemistry project funded by Science Foundation Ireland and the EPSRC. The successful candidate will be employed by Trinity College and the position will be located in the state-of-the-art Trinity Biomedical Sciences Institute which has excellent, newly constructed facilities for synthetic organic chemistry and drug discovery. The project is in collaboration with Dr. Gavin Miller and Prof. Mike Watkinson at the University of Keele, UK. 

The aim of the project is to develop and optimise a novel carbohydrate fluorogenic probe for human haparanase (HPA). Heparanase is an endo-gluceronidase enzyme, responsible for the cleavage of heparan sulfate chains. Expression of heparinase is significantly elevated in most types of cancer tissue and therefore small-molecule probes to monitor its activity are urgently required. The work will involve carbohydrate synthesis, synthetic methodology development, FRET probe development, fluorescent assay development, purification and in vitro analysis of synthetic compounds. 

You should have a PhD with a strong background in one or more of the following areas: synthetic organic chemistry (ideally, working with carbohydrates but training will be provided), synthetic methodology development, FRET probes design and synthesis, high-throughput assays, photophysical characterisation of fluorescent molecules. 

Candidates must have excellent communication skills, which are evident from written reports, presentations and publications and a proven research track record. Publication of appropriate research, attendance at international conferences and public engagement will be encouraged. In addition, candidates will be expected to demonstrate that they are an effective and enthusiastic team member and be prepared to work closely with PhD researchers. The successful candidate will join an established research group with an international reputation. 

This is an excellent opportunity for a postdoctoral scientist who wishes to gain experience of glycan synthesis, and the development of novel biopharmaceuticals.

Applications including a cover letter, CV and contact details for two referees should be made to Prof. Eoin Scanlan (eoin.scanlan@tcd.ie).

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