Postdoctoral position in the area of single-cell genomics

The position is based at unit of Molecular Neurobiology (MBB), at Karolinska Institutet, Stockholm, Sweden, at the Ana Mendanha Falcão research group (also at University of Minho, Portugal) and joint with Castelo-Branco research group.

Ana Mendanha Falcão is a research group leader focusing on the role of the choroid plexus in diseases such as multiple sclerosis. Her team aims to investigate the choroid plexus as a source of biologically active molecules to the central nervous system, in order to influence disease dynamics. The choroid plexus is studied as an alternative target for disease therapies since it can be modulated by peripheral blood and it can substantially alter the brain composition both in terms of biologically active molecules and immune cell content.

The Castelo-Branco research group is interested in the molecular mechanisms defining the epigenetic state of cells of the oligodendrocyte lineage. Our research group has performed single nuclei/cell RNA-Seq  and ATAC-seq and identified several cell states within the oligodendrocyte lineage in development and disease (Nature Medicine 2018, Nature 2019, Neuron 2022), including an immune state that might be relevant for the etiology and/or progression of MS

Your mission

We have ongoing projects with single-cell genomics, and the successful candidates will be actively working in specific projects under Falcao’s group together with Castelo-Branco’s group. The successful candidates will be integrated in a multidisciplinary team comprising computational, molecular and cellular biologists.

Your profile

We are looking for a highly motivated, driven, inquisitive and enthusiastic person interested in our area of research, and ready to explore new avenues in science. The candidates should have a collaborative approach to research, working productively in a team and contributing to a good social environment in the laboratory. The applicants should have competencies in bioinformatics and computational biology and strong programming skills (R and/or Python and/or others), UNIX and LINUX systems knowledge, familiarity with data science a big data. The successful candidate will be working in specific projects involving single-cell genomics on the areas of interest Falcao’s group. Research experience and expertise in analysis of sequencing data is highly desirable. Wet lab experience is not required but it is an advantage.

Qualified to be employed as a postdoctor is one who has obtained a doctorate or has equivalent scientific competence. It is considered as an advantage if you have completed your doctoral degree within the last three years, if there are special reasons, your degree may have been completed earlier. Applicants who have not completed a doctorate at the end of the application period may also apply, provided that all requirements for a completed degree are met before the (intended) date of employment. This must be substantiated by the applicant’s main supervisor, director or equivalent.

What do we offer?

A creative and inspiring environment full of expertise and curiosity. Our research group is based at the Department of Medical Biochemistry and Biophysics (MBB), at the Karolinska Institutet (KI), Stockholm, Sweden, within the Unit of Molecular Neurobiology. The Unit of Molecular Neurobiology has presently seven research groups, focused on several aspects of development, stem cell biology, neuroscience and cancer, providing a unique critical mass and expertize, and vibrant scientific environment. 

Karolinska Institutet is one of the world’s leading medical universities. Our vision is to pursue the development of knowledge about life and to promote a better health for all. At Karolinska Institutet, we conduct successful medical research and hold the largest range of medical education in Sweden. At KI, you get to meet researchers working with a wide range of specialisms and methods, giving you ample opportunity to exchange knowledge and experience with the various scientific fields within medicine and health. It is the crossover collaborations, which have pushed KI to where it is today, at the forefront of global research. Karolinska Institutet is also a state university, which entitles you to several benefits through our collective agreement.

Location: Solna, Biomedicum

Application

Submit your application and supporting documents through the Varbi recruitment system. Use the button in the top right corner and follow the instructions.

An employment application must contain the following documents in English:

1. A complete curriculum vitae, including date of the PhD defense, title of the thesis, previous academic positions, academic title, current position, academic distinctions, and committee work (nor more than 4 pages)
2. A selected list of publications (no more than 2 pages)
3. A personal letter highlighting previous scientific accomplishments, technical expertize and why the candidate is interested in joining the host lab (no more than one page)
4. Verifications for crediting of illness, military service, work for labour unions or student organizations, parental leave or similar circumstances
5. Verification from the thesis defense committee or the equivalent (only if the thesis defense is scheduled within three months after the application deadline)
6. 2 Reference letters (to be uploaded in Varbi if already available, or to be sent directly to ana.mendanha.falcao@ki.se after the first selection round)

Selection
A selection will be made among eligible applicants on the basis of the ability to benefit from doctoral education. The qualifications of the applicants will be evaluated on an overall basis.

Karolinska Institutet uses the following bases of assessment:

– Documented subject knowledge of relevance to the area of research
– Analytical skill
– Other documented knowledge or experience that may be relevant to doctoral studies in the subject.

All applicants will be informed when the recruitment is completed.

Welcome to apply at the latest 2022-08-31

The application is to be submitted through the Varbi recruitment system.

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