Postdoctoral position in identification of novel metabolic targets and differentiation inducing agents in cancer

Do you want to contribute to top quality medical research?

The Department of Microbiology, Tumor and Cell Biology (MTC) at Karolinska Institutet conducts research and teaching within immunology, infection biology, cell biology and cancer. MTC have about 40 research groups and our key words are multidisciplinary, bridging, national and international collaborations

The research group of Marie Arsenian Henriksson conducts research on the MYC family of oncoproteins and network, to uncover their contribution to tumorigenesis, differentiation, metabolism, and apoptosis in different types of cancer. We are a multicultural and dynamic group with many national and international collaborators.

Your mission

We are looking for a highly motivated, skilled, and creative researcher to join our team. The successful candidate will investigate the impact of MYC in metabolic reprogramming to identify novel metabolic proteins that could be used as potential therapeutic targets. Another project concerns alternative strategies involving MYC to induce differentiation of childhood neuroblastoma. The postdoctoral researcher is expected to take a leading role in experimental design, experimental performance, data analysis, and presentation/publication of the results in manuscripts as well as at conferences. The successful candidate should have experience in writing grant application and in supervising international Bachelor and Master students.

Your profile

To be eligible for employment as a postdoctor a doctoral degree or a foreign degree deemed to be equivalent to a doctoral degree is required. This eligibility requirement must be fulfilled at the latest at the time of the employment decision. It is considered as an advantage if you have completed your doctoral degree within the last three years, if there are special reasons, your degree may have been completed earlier.

The candidate should have a high degree of independence but with collaborative mindset, work productively in a team, and contribute to a good social and work environment in the laboratory. The applicant should hold a Ph.D. degree in Biomedical Science and have a solid background in cancer biology. Previous experience in research on tumor metabolism, differentiation, and/or target identification is a prerequisite. Knowledge and experience in the biology of MYC, neuroblastoma, and Bioinformatics is an advantage.

The candidate must be well familiar with standard molecular and cell biology techniques including:

• Advanced cell culture, drug testing and immunofluorescence
• Molecular biology techniques including PCR and Western blot
• Imaging techniques and data analysis
• Metabolic profiling assays
• Sample preparation for Lipidomics, Proteomics and RNAseq
• Lentivirus transduction
• In vivo studies in mice and immunohistochemistry of tumor samples
• Making figures using Graph Pad, Biorender etc

Fluency in written and spoken English is a requirement.

What do we offer?

A creative and inspiring environment with wide-ranging expertise and interests. Karolinska Institutet is one of the world’s leading medical universities. At Karolinska Institutet, we conduct successful medical research and hold the largest range of medical education in Sweden. At KI, you get to meet researchers working with a wide range of specialisms and methods, giving you ample opportunity to exchange knowledge and experience with the various scientific fields within medicine and health. It is the crossover collaborations, which have pushed KI to where it is today, at the forefront of global research. Several of the people you meet in healthcare are educated at KI. A close relationship with the health care providers is important for creating groundbreaking top quality education and research. Karolinska Institutet is also a state university, which entitles you to several benefits through our collective agreement.

Location: Solna

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Application

An employment application must contain the following documents in English or Swedish:

• A complete resumé, including date of the thesis defence, title of the thesis, previous academic positions, academic title, current position, academic distinctions, and committee work
• A complete list of publications
• A summary of current work (no more than one page)

Welcome to apply at the latest 2023-08-31

The application is to be submitted through the Varbi recruitment system.

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