Applications are invited for the position of Research Associate to join the group of Dr Elisa Laurenti within The Wellcome Trust Medical Research Council Cambridge Stem Cell Institute and Department of Haematology on the Cambridge Biomedical Campus. This project will be run jointly by Dr Laurenti and Prof Göttgens, with funding provided by the Aging Biology Foundation. It will characterise how blood ages, by generating a functionally annotated single cell map of the ageing blood stem and progenitor compartment in humans. This will be achieved studying primary human samples in depth by combining many single cell technologies (scRNA-seq/scATACseq, CITE-Seq, WGS and functional assay of blood production coupled with barcoding technologies). A key biological question we aim to address is why the population of blood stem and progenitor cells functionally declines as we age. This will involve defining the cellular and molecular heterogeneity of blood stem and progenitor cells, linking this to functional changes in the production of mature blood cells, and understanding how somatic mutations inevitably acquired with age contribute to the processes above.
Candidates should hold a PhD in a relevant field. They will have a strong background either in haematopoiesis, malignant haematology or ageing. Experience working with primary haematopoietic samples and flow cytometry is required. The candidate should also possess some experience with single cell -omics technologies and/or genomics. Additional expertise of high-throughput sequencing data analysis or of working closely with bioinformaticians would be desirable. Finally, they will have demonstrated a strong scientific achievement via their publication record.
The post holder is expected to creatively and independently carry out their own research project, while collaborating on a regular basis with a team of experimentalists and computational biologists. They will also effectively communicate their work in writing and oral presentations at internal meetings and international conferences.
Fixed-term: The funds for this post are available for 2 years in the first instance.
Once an offer of employment has been accepted, the successful candidate will be required to undergo a health assessment and a security check.
Click the ‘Apply’ button below to register an account with our recruitment system (if you have not already) and apply online.
Please ensure that you upload a covering letter and a CV in the Upload section of the online application. The covering letter should outline how you match the criteria for the post and why you are applying for this role. If you upload any additional documents which have not been requested, we will not be able to consider these as part of your application.
Please include details of your referees, including email address and phone number, one of which must be your most recent line manager.
The closing date for applications is 14th of September 2023.
Interviews are likely to be held on 21th, 22nd and/or 25th of September 2023.
Please quote reference RB37867 on your application and in any correspondence about this vacancy.
The University actively supports equality, diversity and inclusion and encourages applications from all sections of society.
The University has a responsibility to ensure that all employees are eligible to live and work in the UK.
Further information
DEPARTMENT/LOCATION
Wellcome Trust – Medical Research Council Cambridge Stem Cell Institute
SALARY
£36,024-£44,263
REFERENCE
RB37867
CATEGORY
PUBLISHED
1 August 2023
CLOSING DATE
14 September 2023