The Boroviak lab is recruiting a highly enthusiastic individual to carry out ground-breaking research on bioprinting human embryo models.
We will tackle the origin of human body axis formation, which occurs during the second week of gestation. Deeply embedded within extraembryonic tissues, gastrulation transforms the embryonic disc into three germ layers and organizes the future body plan. All of these events are essential for healthy embryo development, but in human they have been notoriously hard to study for ethical and technical reasons.
Building on our insights from spatial profiling of primate gastrulation in utero (Bergmann et al., Nature 2022), the postholder will pioneer next-generation human embryo models to functionally dissect germ layer formation. The research associate will be responsible for driving various bioprinting approaches to emulate embryogenesis in vitro. Validation includes single-cell transcriptomics and spatial-identity-mapping to our existing embryo datasets. Ultimately, the goal is to interrogate the molecular cross-talk between embryonic and extraembryonic lineages with human and marmoset reporter and knock-out pluripotent stem cell lines in bioprinted embryo models.
Located in the heart of Cambridge, our laboratories are based within a multidisciplinary hub for technology and innovation. We operate from two sites, the Centre for Trophoblast Research and the Cambridge Stem Cell Institute with access to state-of-the-art equipment and facility support. This research project is highly collaborative; we are looking for a team player with excellent communication skills. Essential requirements are a PhD or equivalent experience in bioengineering, stem cell biology, bioinformatics or genomics. Most importantly, the ideal candidate will have a can-do attitude with a genuine drive to push boundaries.
Informal enquiries can be directed to Dr. Thorsten Edwin Boroviak (teb45@cam.ac.uk) and further information can be found on our lab website https://boroviaklab.pdn.cam.ac.uk/.
Fixed-term: The funds for this post are available for 2 years in the first instance.
Click the ‘Apply’ button below to register an account with our recruitment system (if you have not already) and apply online.
Please ensure that you upload (i) a covering letter, clearly stating why you would like to join our lab and your future career aspirations, (ii) a one-page research proposal on how to model human development with bioprinting (illustrations welcome, min. font size 10) and (iii) an academic CV with three references.
Please include details of your referees, including email address and phone number, one of which must be your most recent line manager.
The closing date for applications is: 17th September 2023
The interview date for the role is: 28th September and 29th September
Please quote reference PS37605 on your application and in any correspondence about this vacancy.
The University actively supports equality, diversity and inclusion and encourages applications from all sections of society.
The University has a responsibility to ensure that all employees are eligible to live and work in the UK.
Further information
DEPARTMENT/LOCATION
Wellcome Trust – Medical Research Council Cambridge Stem Cell Institute
SALARY
£35,308-£43,155
REFERENCE
PS37605
CATEGORY
PUBLISHED
12 July 2023
CLOSING DATE
17 September 2023