Postdoctoral position in generation of a novel mouse model for neuroblastoma based on human induced pluripotent stem (iPS) cells

Do you want to contribute to top quality medical research?

The Department of Microbiology, Tumor and Cell Biology (MTC) at Karolinska Institutet conducts research and teaching within immunology, infection biology, cell biology and cancer. MTC has about 40 research groups and our key words are multidisciplinary, bridging, national and international collaborations.

The research group of Marie Arsenian Henriksson conducts research on the biology of the pediatric cancer neuroblastoma with the aim to identify its origin, metabolism, and novel therapy options. A large focus is on studies of metabolism which we also perform in medulloblastoma, cervix- and kidney cancer. We are a multicultural and dynamic group with national and international collaborators. 

Your mission

A highly motivated, skilled, and creative researcher is needed to join our team. The successful candidate will spearhead the development of a novel mouse model for neuroblastoma based on human induced pluripotent stem cells and analyze the therapeutic potential of metabolic inhibitors in blocking the processes of tumoral initiation and growth. The postdoctoral researcher is expected to take a leading role in experimental design, in vitro and in vivo assays, data analysis, interpretation, and communication of results both in drafting manuscripts as well as presentations at conferences. The successful candidate should have experience in writing grant applications and in supervising international Bachelor and Master students

Your profile

To be eligible for employment as a postdoctor a doctoral degree or a foreign degree deemed to be equivalent to a doctoral degree is required. This eligibility requirement must be fulfilled at the latest at the time of the employment decision. It is considered as an advantage if you have completed your doctoral degree within the last three years, if there are special reasons, your degree may have been completed earlier.

We are looking for an enthusiastic and self-driven scientist with passion in different fields of cancer research. The candidate should have a high degree of independence but with collaborative mindset, work productively in a team, and contribute to a good social and work environment in the laboratory. The applicant should hold a Ph.D. in Biomedical Science with a solid background in cancer and/or stem cell biology. Previous experience working with cell culture and molecular biology techniques is a prerequisite. Knowledge and experience in developmental biology, neuroblastoma, and bioinformatics is an advantage.

The candidate must be well familiar with:

• Advanced cell culture techniques including iPS cells
• Animal models
• Immunofluorescence and immunohistochemistry
• Molecular biology techniques including RT-qPCR and Western blot
• Imaging techniques and data analysis
• Sample preparation and analysis of bulk and single cell-RNA sequencing
• Preparation of figures using Graph Pad, Biorender etc

Fluency in written and spoken English is a requirement.

What do we offer?

A creative and inspiring environment with wide-ranging expertise and interests. Karolinska Institutet is one of the world’s leading medical universities. At Karolinska Institutet, we conduct successful medical research and hold the largest range of medical education in Sweden. At KI, you get to meet researchers working with a wide range of specialisms and methods, giving you ample opportunity to exchange knowledge and experience with the various scientific fields within medicine and health. It is the crossover collaborations, which have pushed KI to where it is today, at the forefront of global research. Several of the people you meet in healthcare are educated at KI. A close relationship with the health care providers is important for creating groundbreaking top quality education and research. Karolinska Institutet is also a state university, which entitles you to several benefits through our collective agreement.

Location: Solna

Links

Choose to work at KI – Ten reasons why

Application

An employment application must contain the following documents in English or Swedish:

• A complete resumé, including date of the thesis defence, title of the thesis, previous academic positions, academic title, current position, academic distinctions, and committee work
• A complete list of publications
• A summary of current work (no more than one page)

Welcome to apply at the latest 2023-09-01

The application is to be submitted through the Varbi recruitment system.

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