Doctoral student in Medical Science – Translational pediatric cancer research at the University of Gothenburg-Sweden


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Third-cycle studies are equivalent to four year full-time and lead to a Degree of Doctor. Those appointed to doctoral studentships shall primarily devote themselves to their studies. Those appointed to doctoral studentships may, however, work to a limited extent with educational tasks, research and administration. Before a PhD or a doctorate in the fine, applied has been awarded, however, duties of this kind may not comprise more than 20 per cent of a full-time post.

The PhD education in Medical Science comprise carrying out a scientific project and completing at least 30 credits of courses at third-cycle level. The doctoral student must also write a scientific compilation thesis or monograph corresponding to at least 120 credits. For more information about third-cycle studies at Sahlgrenska Academy, see https://medarbetarportalen.gu.se/sahlgrenskaakademin/forskarutbildning/languageId=100001

Project: Despite significantly improved treatment outcomes in most pediatric cancers during the last decades, around 20% of children diagnosed with cancer in industrialized countries still die from their disease. At the same time, severe side effects and long-term complications of chemotherapy and other cancer treatments are frequently reported. Thus, finding the balance between effective treatment and acceptable side effects for each patient is one of the greatest challenges of pediatric cancer management. 

In any cancer of the human body, tumor cells are continuously dying, leading to a leakage of cell-free circulating tumor DNA (ctDNA) into the blood. While ctDNA has emerged as a promising biomarker of disease burden in some adult cancers, its usefulness in pediatric cancer is not known. The aim of this project is to investigate the potential of ctDNA as a biomarker for treatment response and disease recurrence in pediatric cancer.

We include children diagnosed with any type of cancer at the Pediatric Cancer Center, Sahlgrenska University Hospital. We perform sequencing of tumor and normal DNA, and determine the full spectrum of genetic alterations for each patient. We then collect serial blood samples and analyze the amount of ctDNA before, during and after treatment to monitor response, analyze minimal residual disease, and detect early signs of disease relapse. 

If this method is proven successful, it may be used to optimize the treatment for each individual patient. It may also reduce the need for more invasive and potentially harmful methods to monitor treatment response, such as bone marrow biopsies in leukemia and repeated CT scans in solid tumors.

This position will be focused on the laboratory side of the project, and you will not be in contact with patients.

Eligibility

To be eligible for third-cycle studies, the applicant must meet both the general and specific entry requirements.

A person meets the general entry requirements for third-cycle studies if he or she: 
1. has been awarded a second-cycle qualification 
2. has satisfied the requirements for courses comprising at least 240 credits of which at least 60 credits were awarded in the second-cycle, or 
3. has acquired substantially equivalent knowledge in some other way in Sweden or abroad

A person meets the specific entry requirements for third-cycle studies if he or she: has successfully completed the English B/6 course or is considered to have acquired equivalent knowledge through previous studies

Assessment

In selecting between applicants who meet the general and specific entry requirements, their ability to benefit from third-cycle studies shall be taken into account. The assessment shall attach particular importance to documented qualifications for: 
– specific knowledge and skills within the subject area and related research fields 
– experience of scientific theory and relevant research methodology 
– scientific analysis and presentation verified through thesis, degree project, scientific journals or the like.

Employment

After admission to third-cycle studies you will be appointed to doctoral studentship. Regulations for employment of doctoral students are given in SFS 1993:100. The initial appointment may apply for no longer than one year. An appointment may be renewed for no more than two years at a time. A person may be appointed to a doctoral studentship for a total of eight years. The total employment period may, however, not exceed the time corresponding to full-time third-cycle study for four years.

Location: Sahlgrenska Academy, Institute of Clinical Sciences, Department of Pediatrics. Extent: 100%. First day of employment: as agreed.

Salaries for doctoral students are regulated in a local agreement at the University.

For further information regarding the position

For more information about the project please contact the principal supervisor, 
Martin Dalin, martin.dalin@gu.se

Unions

Union representatives at the University of Gothenburg: http://www.gu.se/english/about_the_university/job-opportunities/union-representatives

How to apply

In order to apply for a position at the University of Gothenburg, you have to register an account in our online recruitment system. It is the responsibility of the applicant to ensure that the application is complete in accordance with the instructions in the job advertisement, and that it is submitted before the deadline. The selection of candidates is made on the basis of the qualifications registered in the application.

You must include the following, in pdf format

  • Personal letter
  • CV
  • Diploma and transcripts showing that you meet with the general entry requirement
  • Proof of completion of  English 6 course or the acquired equivalent knowledge through previous studies

If your degree is from a university outside of Sweden, check what you need to submit at https://www.universityadmissions.se/en/All-you-need-to-know1/Applying-for-studies/Documenting-your-eligibility-for-studies/Instructions-for-Masters-applicants/Specific-requirements-for-my-country1/ where you can also see what you need to submit in order to fulfill the English language requirement.

  • If your degree has not been verified by a Swedish authority you need to provide contact details to the issuing university, registrar or similar, that can verify the degree at our request.

Closing date: 2019-03-19 

Diary id: PAR 2019/260

The University of Gothenburg promotes equal opportunities, equality and diversity.

Applications will be destroyed or returned (upon request) two years after the decision of employment has become final. Applications from the employed and from those who appeal the decision will not be returned.

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